Blog
Decision-ready Data: Make the Call with Confidence, Not Crossed Fingers
In high-stakes drug discovery, teams are often asked to commit millions of dollars, months of work, and organisational credibility based on data generated early in the process. The science may l...
CETSA Explained
Cellular Thermal Shift Assay (CETSA®) is an innovative, robust method that measures drug-target interactions directly within living cells and tissues under physiologically relevant conditions. CETSA u...
Advancing Natural Product Drug Discovery with CETSA: Insights from Recent Research
Natural products continue to provide a valuable source of novel bioactive compounds. However, their structural complexity and potential for multi-target engagement have often made target identificatio...
The Top 5 Drug Discovery Trends Defining 2025: What They Mean for the Future of Innovation
Introduction: Navigating a Transformative Year in Drug Discovery Drug Discovery Trends 2025 are driving a transformative shift across early-stage research and development. The pressure to reduce...
Cracking the Code of Mutant p53: A CETSA®-Powered Investigation at AACR 2025
Our mutant p53 CETSA AACR study reveals novel findings in cancer biology. The tumor suppressor p53, often lauded as the “guardian of the genome,” orchestrates critical cellular decisions such as cell ...
What Makes a High-Quality Hit in Early Drug Discovery?
Why enhancing confidence in primary screening is critical to translational success—and how emerging methodologies are redefining hit validation High quality hits in drug discovery are essential ...
What Is Unbiased Selectivity Profiling? A CETSA®-Based Approach to Drug Discovery
CETSA selectivity profiling is crucial in pursuing safer and more efficacious therapeutics. Comprehensively characterizing how small molecules interact across the proteome is increasingly recognized a...
Accelerating Drug Discovery with Proteome-Wide CETSA® Profiling: Why Timing Is Everything
At Pelago Bioscience, we work with drug discovery teams to optimize their approach to target identification and mechanism of action (MoA) elucidation. As drug discovery grows increasingly complex and ...
Why Drug Candidates Fail During Development: The Challenges of Target Engagement
Importance of Target Engagement in Drug Discovery Despite billions invested in drug development, more than 90% of clinical drug candidates fail. A lack of target engagement causes a significant propor...
Using CETSA® to Measure Target Engagement in Whole Blood
Validating target engagement is a crucial step in drug development, helping us understand how a drug interacts with its intended target and linking that interaction to its clinical effects. As therapi...
Are Your Degraders Delivering on Their Promise?
Biologically Relevant Insights for Protein Degraders with CETSA® Targeted protein degradation has emerged as one of the most exciting innovations in drug discovery. It provides a way to eliminat...
Is Your Hit on Target?
How to Confidently Validate Drug Discovery Hits High-throughput screening (HTS) is a powerful tool for identifying chemical starting points in drug discovery. But not all hits are created equal. Many ...