Precision with scale, measure what matters

Targeted CETSA® profiling focuses on specific proteins when clear hypotheses or candidate targets are already available. By measuring thermal stability changes in defined proteins, this approach provides focused and quantitative evidence of cellular target engagement.

Targeted profiling with CETSA supports assay development in intact cells, enables scalable screening designs, and provides direct evidence of target engagement under physiologically relevant conditions. The approach can help identify novel chemotypes, differentiate mechanisms among compounds with similar potency, and highlight cases where functional effects do not align with enzymatic inhibition or expected binding modes.

The method is therefore helpful when validating mechanistic hypotheses and confirming that on-target engagement occurs in the intended cellular context.

The path of a Targeted project

A quick look at how it works

Start-Up

– Project Start-Up

Plan your project with our dedicated scientists. Together, we align on study design, project scope and timelines to ensure a strong foundation for the work ahead.

Processing

– We do the work

We use well established workflows and state-of-the-art equipment to perform the project. We stay in touch with you throughout. Once data is generated, we do a thorough analysis.

Insights

– Results with expert interpretation

When the analysis is complete, we share the results with you, guide you through the key findings and discuss how they connect to your research goals, scientist-to-scientist.