Unbiased insights into your compound

Unbiased CETSA® profiling enables you to observe how a compound influences proteins and pathways across the proteome without relying on predefined targets or assumptions. By monitoring thermal stability changes in intact, disease-relevant cells, this approach captures both direct binding events and downstream responses that reflect broader network biology.

An unbiased discovery-driven approach is particularly useful in early research when biological knowledge is limited, when phenotypes are complex, or when you need to explore new chemical matter without restricting the experiment to known mechanisms. Unbiased profiling can highlight early mechanistic clues, reveal unexpected connections, and help distinguish compounds based on how selectively or broadly they perturb cellular systems.

The results can guide future decision-making, whether toward deeper proteome-wide investigation, targeted validation, or a structured mechanistic study. Unbiased profiling can also complement targeted assays when you want to compare directed hypotheses with emergent proteome-level behaviour.