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Proteome-wide CETSA® profiling is a mass spectrometry-based method measuring compound-induced changes across thousands of proteins simultaneously. This enables detection of both direct target engagement and indirect pathway responses, providing a broad and physiologically relevant view of compound activity.

This broad coverage helps uncover the molecular basis of compound activity, clarifies mechanisms that drive phenotypic outcomes, and identifies potential off-target effects that isolated biochemical assays often miss. Proteome-wide data can also support structure–activity exploration by showing how chemical changes influence engagement or pathway signatures.

The depth and relevance of the data make proteome-wide CETSA ideal when the target is unknown, when multiple pathways may contribute to activity, or when early mechanistic insight is needed to support progression decisions.

Proteome-Wide Profiling is a highly customizable service, each project is designed to the biological context of your research question.

The path of a Proteome-Wide project

A quick look at how it works

Start-up

– Project Start-Up

Plan your project with our dedicated scientists. Together, we align on study design, project scope and timelines to ensure a strong foundation for the work ahead.

Processing

– We do the work

We use well established workflows and state-of-the-art equipment to perform the project. We stay in touch with you throughout. Once data is generated, we do a thorough analysis.

Insights

– Results with expert interpretation

When the analysis is complete, we share the results with you, guide you through the key findings and discuss how they connect to your research goals, scientist-to-scientist.