Pelago Services

CETSA® allows the study of target engagement of compounds in a cellular context. But it is the expertise of our target engagement teams that transforms an elegant technology into early insights and actionable data – customized for your purpose, scope and stage in the drug discovery process.

That’s why we ensure that our services come with the full support and know-how of a dedicated team with experience from hundreds of drug discovery projects: CETSA® by Pelago Bioscience.

Explore, discover and confirm with CETSA®

How can we help you?

Pelago Bioscience is a specialized CRO, focusing on biologically relevant assays with our patented CETSA® technology as its core. We provide bespoke projects in a wide range of service areas, from target discovery, to lead generation, optimization and confirmation.

Our services are based on three flexible product formats that allow our customers to define the scope and value they are looking for:
CETSA® Navigate enables rapid target engagement confirmation, CETSA® Navigate HT is for efficient high-throughput discovery, and CETSA® Explore is a Mass Spectrometry-based approach allowing unbiased proteome-wide investigation.

Extending beyond our services we offer license agreements enabling you to utilize the CETSA® technology in-house. A single target license can be acquired for a specific target and provides the right to use the specified CETSA® format for that target.

In a partnership with PerkinElmer we provide Alpha CETSA® kits, for selected fully validated targets. We have also pre-validated over 40 total AlphaLISA SureFire®  Ultra protein kit targets proving that they are amenable to CETSA® . These protein targets are now available as CETSA® ble kits.

A wide range of services from early discovery to confirmation

Our CETSA® teams offer a range of customized services, designed to help you make better decisions faster, no matter where you are in the drug discovery process.

True target engagement assessment

Target
Identification

Lead
generation

Lead
optimization

Preclinical
studies

Clinical
trials

Approved
drugs

Target Identification

CETSA® Explore (also known as TPP or PISA) combines the power of Mass Spectrometry with CETSA® and allows for unbiased proteome-wide target identification. Being unbiased and hypothesis–free, CETSA® Explore can be used for target deconvolution studies for hit compounds from phenotypic screens. Since CETSA® can be performed in any sample matrix, the profiling and deconvolution can be conducted directly in disease relevant systems.

Lead Generation

CETSA® Navigate HT is a perfect tool to unlock novel chemistry in lead generation programs using compound library sets of up to 500k. Or alternatively use CETSA® Navigate for rapid hit confirmation or the CETSA® Explore for proteome-wide profiling of lead compounds.

Lead Optimisation

CETSA® Navigate and Navigate HT are both commonly used within lead optimization programs, with the choice being dependent on the number of compounds tested.  Navigate HT offers greater volumes at lower data point costs in shorter time. Navigate provides a faster assay development and is applicable to a wider range of assay matrices and therefore an ideal format to progress into translational studies. In addition, the CETSA® Explore can assess the selectivity profile of the lead series to highlight safety issues that needs to be addressed.

Preclinical Studies

CETSA® Navigate’s flexibility makes it the first choice for translations studies where confirming target engagement within tissue samples is required and in patient derived material can provide a vital clue to the drug candidate probable efficacy in human studies.

Clinical Trials

Biomarkers are important to facilitate translation, validate the therapeutic hypothesis and monitor effects in clinical trials and beyond. CETSA® Explore can be used to identify novel markers that would not be identified by conventional ‘omics approaches, and if necessary CETSA® Navigate or Navigate HT can be used to monitor these in patient samples once the biomarker has been identified.

Approved drugs

Many drugs have poorly understood, complex and diverse modes of action. CETSA® Explore is a powerful tool that provides deep insights into the selectivity and action of drugs. These insights can be used to identify drug repurposing opportunities, drug synergy and new targets.

Explore our knowledge center to discover additional applications for the CETSA® formats.

At AstraZeneca we are applying CETSA® HT in high-throughput screening and lead optimization to identify and characterize hit and lead compounds for a number of novel targets.

Thomas LundbäckAssociate director, AstraZeneca

Reduce timelines by up to 12 months

“Adopting CETSA® can reduce your project timeline by 6-12 months and expedite the progress of compounds from lead generation into the lead optimization stage“

Stina Lundgren,
Drug discovery expert,
Pelago Bioscience

Identifying ECM29 predictive biomarker

“It would have been almost impossible to identify the ECM29 predictive biomarker of breast cancer without CETSA® MS“

Teemu P Miettinen,
Research fellow,
MIT

An excellent collaboration partner

“I enjoyed very much working with the team at Pelago Bioscience, an excellent collaboration partner. It’s always great to work with such a group of professional people. Thank you“

Margarita Garcia-Calvo,
Principal Scientist,
Lodo Therapeutics

Speak to our experts

Learn how CETSA® can enable your project by talking to one of our Drug Discovery experts