Lead Optimization In Drug Discovery
Fine-tune
your leads
We show what your compounds really do inside cells and reveal real-world target engagement and off-target effects, so you can push the best molecules forward with clarity.
Potency Ranking
Prioritize compounds to lower the risk of failures in later development stages.
Selectivity Profiling
Reveal off-target interactions with unbiased, proteome-wide profiling.
Target Identification and Deconvolution
See compound-target interactions in conditions that reflect actual cellular environments.
Mechanism of Action
Gain a clear understanding of compound activity across the proteome in biologically relevant conditions.
Translational Studies
Confirm target engagement across cell lines, animal tissues, and human-derived systems for reliable translational insights.
Why CETSA?
What makes CETSA different?
See CETSA in action
Read our case stories.
Unlocking Challenging Targets with CETSA® Across Drug Discovery
Drug discovery increasingly focuses on targets that are difficult to address using traditional approaches. CETSA® enables direct measurement of target engagement in intact cells and complex biological …
Engaged but not degraded
Target engagement profiling of degrader compounds with CETSA CETSA® (Cellular Thermal Shift Assay) is a label-free method for studying small molecule-protein interactions and is especially useful in ta…
On Target Driven Efficacy Assessment of CDK2 Inhibitors in the Right Biological Context
Target Engagement and Selectivity Profiling in K562 and MCF7 Cells CETSA® is a label-free method for assessing target engagement of small molecule-protein interactions. Target engagement determination …