Webinar: Novel Applications of the Cellular Thermal Shift Assay (CETSA) Provide New Insights for Drug Discovery

Join AbbVie scientists Shitalben Patel, MSc and Jami R. Erickson, PhD as they present innovative advancements in CETSA® technology — transforming it into a high-throughput, flow-based platform and developing new whole blood assay formats that bring target engagement measurement closer to patient samples.

In this session, you will learn about:

• High-Throughput CETSA Innovation: Learn about the flow-based adaptation of CETSA, enabling rapid, large-scale compound screening using 384-well plates.
• Flow Cytometry-Based Methodology: Discover how this technique detects thermostabilized proteins without cell lysis, allowing detailed single-cell analysis.
• Application in Drug Discovery: See how flow-based CETSA integrates into SAR funnels, accelerating hit generation for endogenous targets in native cells.
• Whole Blood CETSA Development: Explore two novel formats—Alpha CETSA and MSD CETSA—that use <100 μL blood and eliminate PBMC isolation.
• Clinical Relevance: These blood-based assays enable direct, scalable target engagement readouts and support asynchronous, centralized clinical workflows
• Translational Potential: Together, these innovations bridge preclinical research and clinical application, streamlining drug development in native biological systems.

Featured Speakers

Shitalben Patel

Scientist Chemical Biology and Mass Spectrometry Technology, Discovery Research
AbbVie

Shitalben Patel is a Scientist in the chemical biology group at AbbVie. Her role involves developing high-throughput chemoproteomics workflows, employing chemical biology technologies to understand drug-target engagement, on and off-target selectivity profiling, as well as mechanism-of-action for small molecule drug discovery.stage drug development. 

Jami R. Erickson

Senior Scientist
Molecular Screening and Characterization, Discovery Research
AbbVie

Dr. Jami R. Erickson is a Senior Scientist in the molecular screening and characterization group at AbbVie in North Chicago. Her work focuses on high-throughput screening and innovative technique development, including the pioneering of flow-based CETSA techniques.

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