Posters
Unbiased Selectivity Profiling: with CETSA® and Mass Spectrometry
Unbiased Selectivity Profiling: Revealing True Compound Specificity and Off-Target Interactions CETSA mass spectrometry profiling enables unbiased analysis of compound selectivity in drug discovery—he...
Employing CETSA® in Primary Screening for p53 Binders
CETSA p53 Screening: Uncovering Potential Cancer Therapeutics Targeting p53, a key tumor suppressor protein often labeled “undruggable,” poses a major challenge in oncology research. Yet, ...
Enhancing Degrader Research with CETSA®
Unlocking New Insights into Targeted Protein Degradation with CETSA: Revealing Both Target Engagement and Off-Target Effects In the rapidly evolving field of targeted protein degradation (TPD), unders...
Dissecting the Biology of Mutant p53 with CETSA®
Unlocking the Complex Biology of Mutant p53 with CETSA: Revealing Target Engagement and Stability Profiles p53 target engagement is a critical factor in modern cancer drug discovery. The tumor suppres...
Enhancing Primary Screening with CETSA: A Case Study in CDK4 Hit Identification
Whether exploring challenging targets or optimizing your screening approach, this poster illustrates how CETSA can unlock new insights and help prioritize the right leads faster. Download now to...
Unbiased Selectivity Profiling, CETSA with MS detection
Unbiased analysis of compound selectivity Selectivity in drug development is an essential prerequisite for the generation of lead candidates. The limited number of proteins profiled in traditional pan...
CETSA as a tool for assessing selectivity of warheads and PROTACS and for detecting binders that remain intact
CETSA® (Cellular Thermal Shift Assay) is an effective method for studying interactions between small molecules and their protein targets, particularly useful in targeted protein degradation (TPD) as i...