See what your protein degrader
is really doing – in cells, without constraints
CETSA® (Cellular Thermal Shift Assay) from Pelago Bioscience identifies wanted and un-wanted neosubstrates, correlates degradation with target engagement for confidence and better understanding of mechanism of action (MoA).
If you’ve ever felt slowed down by assay limitations or doubt in what your data is really showing, you’re exactly who CETSA was built for.
Why scientists choose CETSA :
- See everything at once – true degradation + unexpected off-targets in the same native-cell readout
- No labels. Any matrix, including patient-relevant primary cells
- Scientist-to-scientist expertise included – interpretation support from the Pelago Bioscience team
- Faster, clearer, more confident Go/No-Go decisions
Application note:
Is your hit on target?
Learn how you can identify, validate, and optimize hits directly in unmodified cellular systems.
Application note:
Are your degraders delivering?
Discover how CETSA supports degrader development through precise target engagement insights.
Article:
A Tale of Two Tails
Efficient Profiling of Protein Degraders by Specific Functional and Target Engagement Readouts
Poster:
Enhancing degrader research with CETSA
Read our findings from a high-throughput CETSA screening campaign profiling various small molecule degraders, including PROTACs, in intact cells and lysates.
Poster:
CETSA as a framework for degrader validation
This study uses CDK9-directed degraders to show how CETSA combines live-cell degradation data, target engagement analysis, and reveal the degrader’s mechanism of action.
We are happy to discuss your current degrader and assay strategy, wherever you are in the pipeline.
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