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Unlocking Challenging Targets with CETSA® Across Drug Discovery
Drug discovery increasingly focuses on targets that are difficult to address using traditional approaches. CETSA® enables direct measurement of target engagement in intact cells and complex biological …
Engaged but not degraded
Target engagement profiling of degrader compounds with CETSA CETSA® (Cellular Thermal Shift Assay) is a label-free method for studying small molecule-protein interactions and is especially useful in ta…
On Target Driven Efficacy Assessment of CDK2 Inhibitors in the Right Biological Context
Target Engagement and Selectivity Profiling in K562 and MCF7 Cells CETSA® is a label-free method for assessing target engagement of small molecule-protein interactions. Target engagement determination …
Novel Applications of the Cellular Thermal Shift Assay (CETSA) Provide New Insights for Drug Discovery
Join AbbVie scientists Shitalben Patel and Jami R. Erickson as they showcase their innovative advancements, transforming CETSA® into a high-throughput flow-based platform and introducing new whole blo…
Unbiased Selectivity Profiling: with CETSA® and Mass Spectrometry
Unbiased Selectivity Profiling: Revealing True Compound Specificity and Off-Target Interactions CETSA mass spectrometry profiling enables unbiased analysis of compound selectivity in drug discovery—he…