Target Engagement Assay Drug Discovery
Target engagement
where it matters:
in cells
With Cellular Thermal Shift Assay (CETSA®), we uncover
how compounds bind to their target – directly in cells.
10 +
Years of experience
350+
Customers including top 10 big pharma
750+
CETSA projects
800+
References annually
Cellular insights for every
stage of early discovery
Our CETSA technology delivers direct evidence of protein behavior in their native environment, the cell, providing a clear link across the drug discovery pipeline.
Target Based Discovery
Phenotypic Discovery
One assay, endless possibilities
Turn complex biology into actionable insights across the entire discovery pipeline.
“Dedicated to getting the best results possible”
Generian Pharmaceuticals is developing oral small molecules for clinically validated targets in markets still dominated by biologics. Working with Pelago Bioscience, the company uses CETSA® to screen its proprietary library against unmodified proteins in their natural biological context.
Hank Safferstein, CEO Generian Pharmaceuticals, explains why they decided to work with Pelago Bioscience and how CETSA was used to screen their compound library.
Target
Discovery
Discover better drug targets, faster. See how proteins behave in real cells, and turn complex biology into clear, actionable insights.
Lead
Generation
Turn promising hits into proven leads. We help you see how compounds engage their targets in real cells – so you can focus on molecules that truly work.
Lead Optimization
We help you fine-tune your leads. We show what your compounds really do inside cells and reveal real-world target engagement and off-target effects, so you can push the best molecules forward with clarity.
Preclinical Studies
Move forward with confidence. Guide smarter preclinical decisions -helping you choose the right candidates to advance.
Discover better drug
targets, faster
It all started with a new
way to see biology
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