Target Engagement Assay Drug Discovery

Target engagement
where it matters:
in cells

With Cellular Thermal Shift Assay (CETSA®), we uncover
how compounds bind to their target – directly in cells.

Our services

Why CETSA?

10 +

Years of experience

350+

Customers including top 10 big pharma

750+

CETSA projects

800+

References annually

Cellular insights for every
stage of early discovery

Our CETSA technology delivers direct evidence of protein behavior in their native environment, the cell, providing a clear link across the drug discovery pipeline.

Screen smarter, faster Get early validation and make more informed decisions

Target Based Discovery

Target Discovery

Hit Identification

Phenotypic Discovery

Hit Identification

Target Deconvolution

Lead Generation

Lead optimization

Preclinical Studies

Uncover off-target effects early Get unbiased insights

One assay, endless possibilities

Turn complex biology into actionable insights across the entire discovery pipeline.

Unbiased Profiling Services

Observe how a compound influences proteins and pathways across the proteome without relying on predefined targets or assumptions.

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Targeted Profiling Services

Validate mechanistic hypotheses and confirm that on-target engagement occurs in the intended cellular context.

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Target
Discovery

Discover better drug targets, faster. See how proteins behave in real cells, and turn complex biology into clear, actionable insights.

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Lead
Generation

Turn promising hits into proven leads. We help you see how compounds engage their targets in real cells – so you can focus on molecules that truly work.

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Lead Optimization

We help you fine-tune your leads. We show what your compounds really do inside cells and reveal real-world target engagement and off-target effects, so you can push the best molecules forward with clarity.

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