Target Engagement Assay Drug Discovery
Target engagement
where it matters:
in cells
With Cellular Thermal Shift Assay (CETSA®), we uncover
how compounds bind to their target – directly in cells.
10 +
Years of experience
350+
Customers including top 10 big pharma
750+
CETSA projects
800+
References annually
Cellular insights for every
stage of early discovery
Our CETSA technology delivers direct evidence of protein behavior in their native environment, the cell, providing a clear link across the drug discovery pipeline.
Target Based Discovery
Phenotypic Discovery
One assay, endless possibilities
Turn complex biology into actionable insights across the entire discovery pipeline.
CETSA Selectivity. Now available in intact cells.
What if you didn’t have to choose between breadth and biological context? Panel-based assays are powerful. But they only show you what you decide to look for. Broader proteomics can reveal more. But often at the cost of speed and simplicity.This is why we developed CETSA Selectivity.
Now, we’re expanding the service from lysate to intact cells. That means you can compare compounds across thousands of proteins while keeping the biology of the living cell intact.
Target
Discovery
Discover better drug targets, faster. See how proteins behave in real cells, and turn complex biology into clear, actionable insights.
Lead
Generation
Turn promising hits into proven leads. We help you see how compounds engage their targets in real cells – so you can focus on molecules that truly work.
Lead Optimization
We help you fine-tune your leads. We show what your compounds really do inside cells and reveal real-world target engagement and off-target effects, so you can push the best molecules forward with clarity.
Preclinical Studies
Move forward with confidence. Guide smarter preclinical decisions -helping you choose the right candidates to advance.
Discover better drug
targets, faster
It all started with a new
way to see biology
News & Events
261014
Webinar: Mapping degrader activity and selectivity in intact cells
Explore how cereblon allostery and cellular target engagement profiling can reveal the m…
261014
Webinar: Smarter Drug Discovery: Turning Screening Hits into Opportunities
5 November 2026 17:00 CET | 16:00 GMT | 11:00 EST | 08:00 PST Virtual screening and frag…
260922
Meet us at Chemical Biology at the Hub
Location: The Broad Institute, Cambridge, MA Date: Sep 30
260916
Meet us at TPD & Induced Proximity Summit
We’re attending TPD & Induced Proximity Summit in Boston, MA Date: 26 – …
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