Mapping drug discovery decisions with CETSA: CDK4 as a use case
This poster shows how CETSA® can support better decision-making at key stages of drug discovery, from early hit assessment to translational studies. Using CDK4 as a practical example, it highlights how target engagement data helps teams evaluate compound behavior, compare chemical series, investigate selectivity, and build confidence before advancing programs.
Targeted Protein Degradation – Enhancing Degrader Research with CETSA®
Unlocking New Insights into Targeted Protein Degradation with CETSA: Revealing Both Target Engagement and Off-Target Effects In the rapidly evolving field of targeted protein degradation (TPD), unders…
Dissecting the Biology of Mutant p53 with CETSA®
Unlocking the Complex Biology of Mutant p53 with CETSA: Revealing Target Engagement and Stability Profiles p53 target engagement is a critical factor in modern cancer drug discovery. The tumor suppres…
CETSA as a tool for assessing selectivity of warheads and PROTACS and for detecting binders that remain intact
CETSA® (Cellular Thermal Shift Assay) is an effective method for studying interactions between small molecules and their protein targets, particularly useful in targeted protein degradation (TPD) as i…