Explore how cereblon allostery and cellular target engagement profiling can reveal the mechanisms and selectivity underlying degrader activity.
11 November 2026
17:00 CET | 16:00 GMT | 11:00 EST | 08:00 PST
Targeted protein degradation relies on productive interactions between degraders, E3 ubiquitin ligases, and recruited neosubstrates. Understanding how these interactions are regulated and distinguishing binding events from downstream degradation can provide deeper insight into degrader activity and selectivity.
In this webinar, Vanessa Dippon PhD, Postdoctoral Fellow, Broad Institute of MIT and Harvard, and Tomas Friman PhD, Principal Scientist, Pelago Bioscience will discuss the discovery of a cryptic allosteric pocket on cereblon, its effects on ligand binding and neosubstrate degradation, and the use of the Cellular Thermal Shift Assay (CETSA) coupled to mass spectrometry to profile degrader binding interactions and selectivity in intact cells.
Topics to be covered:
- Comparison of PROTAC and molecular glue degrader activity
- Discovery and structural characterization of an allosteric cereblon pocket
- Effects of cereblon allostery on ligand binding and neosubstrate degradation
- Cellular profiling of degrader binding interactions and selectivity using CETSA
