Enhancing Degrader Research with CETSA®

Unlocking New Insights into Targeted Protein Degradation with CETSA: Revealing Both Target Engagement and Off-Target Effects In the rapidly evolving field of targeted protein degradation (TPD), understanding how PROTACs (Proteolysis-targeting chimeras) engage and degrade their targets is critical. Our research leverages CETSA PROTAC profiling to provide deeper insights into degrader efficacy by measuring both target engagement and off-target degradation in live cells. How CETSA PROTAC Profiling Advances Targeted Degrader Research CETSA (Cellular Thermal Shift Assay) is a robust, label-free method that enables direct detection of protein stability changes in response to compound binding. This technology empowers researchers to identify true protein binders, evaluate degradation outcomes, an...