Posters
Unlocking Challenging Targets with CETSA® Across Drug Discovery
Drug discovery increasingly focuses on targets that are difficult to address using traditional approaches. CETSA® enables direct measurement of target engagement in intact cells and complex biological ...
Engaged but not degraded
Target engagement profiling of degrader compounds with CETSA CETSA® (Cellular Thermal Shift Assay) is a label-free method for studying small molecule-protein interactions and is especially useful in ta...
On Target Driven Efficacy Assessment of CDK2 Inhibitors in the Right Biological Context
Target Engagement and Selectivity Profiling in K562 and MCF7 Cells CETSA® is a label-free method for assessing target engagement of small molecule-protein interactions. Target engagement determination ...
Unbiased Selectivity Profiling: with CETSA® and Mass Spectrometry
Unbiased Selectivity Profiling: Revealing True Compound Specificity and Off-Target Interactions CETSA mass spectrometry profiling enables unbiased analysis of compound selectivity in drug discovery—he...
p53 Targeted Therapy: Employing CETSA® in Primary Screening for p53 Binders
CETSA p53 Screening: Uncovering Potential Cancer Therapeutics Targeting p53, a key tumor suppressor protein often labeled “undruggable,” poses a major challenge in oncology research. Yet, ...
Targeted Protein Degradation – Enhancing Degrader Research with CETSA®
Unlocking New Insights into Targeted Protein Degradation with CETSA: Revealing Both Target Engagement and Off-Target Effects In the rapidly evolving field of targeted protein degradation (TPD), unders...
Dissecting the Biology of Mutant p53 with CETSA®
Unlocking the Complex Biology of Mutant p53 with CETSA: Revealing Target Engagement and Stability Profiles p53 target engagement is a critical factor in modern cancer drug discovery. The tumor suppres...
Enhancing Primary Screening with CETSA: A Case Study in CDK4 Hit Identification
Whether exploring challenging targets or optimizing your screening approach, this poster illustrates how CETSA can unlock new insights and help prioritize the right leads faster. Download now to...
Unbiased Selectivity Profiling, CETSA with MS detection
Unbiased analysis of compound selectivity Selectivity in drug development is an essential prerequisite for the generation of lead candidates. The limited number of proteins profiled in traditional pan...
CETSA as a tool for assessing selectivity of warheads and PROTACS and for detecting binders that remain intact
CETSA® (Cellular Thermal Shift Assay) is an effective method for studying interactions between small molecules and their protein targets, particularly useful in targeted protein degradation (TPD) as i...