Enhancing Degrader Research with CETSA®

Unlocking New Insights into Targeted Protein Degradation with CETSA: Revealing Both Target Engagement and Off-Target Effects In the rapidly evolving field of targeted protein degradation (TPD), understanding the complex mechanisms of PROTACs (Proteolysis-targeting chimeras) is crucial. Our research leverages CETSA (Cellular Thermal Shift Assay) to gain deeper insights into PROTAC efficacy by measuring target engagement and degradation. Using this powerful, label-free technology, we identify direct protein binders and evaluate cellular responses, providing a clearer picture of both degradation and off-target effects.targets like CDK4. In this academic poster, we share results from a recent high-throughput screening campaign that demonstrates the value of CETSA in identifying and validating ...