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Welcome to Pelago Knowledge Center
We hope you will enjoy our collection of resources, information and facts.
A majority of drug candidates fail in clinical trials. Many of them fail in late proof-of-concept studies due to a lack of efficacy, which results in increased costs and lost time. This waste of time and resources can be avoided by applying target engagement studies with high accuracy and predictive value early and continuously in the drug discovery value chain. Select a topic to begin.
Webinars by Pelago
We share the latest technology updates and project updates from our clients by hosting webinars frequently. If you missed any of our previous webinars or would like to revisit a particular topic, you can now do so by visiting our website and accessing the recordings.
Compound Evaluation and Potency Ranking
Including CETSA® in your assay cascade and using the EC50 data for potency ranking within your chemical series facilitates a relevant compound design yielding compounds with higher chance of therapeutic effect.
Selectivity
In drug discovery, selective binding of the compound to the right target is important for the drug to be both effective and safe. To achieve this, the drug must be present at the site of action and occupy the intended target with high specificity.
Mechanism of Action for Degraders
Targeted protein degradation is a novel modality with the potential to tackle therapeutically interesting proteins beyond the limitations of current existing approaches. In this area, CETSA® is a powerful technology which can be applied for investigating the degradation target
Target Engagement
For a drug to be effective according to the target hypothesis, it must selectively bind to the intended target protein to elicit its effect. Target engagement (TE) is defined as the interaction of ligands with their molecular targets. Assessment of a compound’s TE is essential in the discovery and development of new therapies.
Library Screening
CETSA® can determine cellular target engagement in physiologically relevant settings of the native, full-length protein and can potentially unlock novel chemical space. CETSA® library screening in intact cells gives direct confirmation on target engagement of your library compounds in physiological conditions from the onset.
Hit Confirmation
As a cellular target engagement assay that determines the level of interaction between a ligand and a target protein of interest in a physiologically relevant setting, CETSA® is perfectly suited for hit confirmation.