Is your hit on target?

The patented Cellular Thermal Shift Assay, CETSA® can determine target engagement in physiologically relevant settings and therefore reduce the failure rates and associated high costs of drug discovery programs. The adaptation of CETSA® into a microtiter plate format enables compound screening with high-throughput: CETSA® Navigate HT, with applications in hit identification, confirmation and lead generation

CETSA® Navigate HT can evaluate target engagement in the relevant physiological environment

  • As drug discovery strives to become more efficient at delivering successful clinical drug candidates, cell-based assays need to better reflect the targeted disease. One key advantage of CETSA® Navigate HT is the potential to confirm that compound mediated cellular effects are a consequence of target engagement in cells.
  • CETSA® Navigate HT can be applied to various stages of drug discovery from hit identification to candidate drug selection

How can I confirm if my hit is on target? Download our CETSA® Navigate HT application note.


  1. Jafari et al.Nature Protocols 2014

  2. Rowlands et al. SLAS Discovery 2023
  3. Shaw et al. SLAS Discovery 2018

Speak to our experts

Learn how CETSA® can enable your project by talking to one of our Drug Discovery experts.