How does cellular target engagement relate to efficacy?
The patented Cellular Thermal Shift Assay (CETSA®) helps you to circumvent this persistent problem. CETSA® EC50 determines the potency of compounds directly in the cells or tissues of interest, providing crucial information about target engagement independent from function, early in the drug discovery pipeline.
CETSA® EC50 correlates with other measures of affinity.
- CETSA® EC50 provides you with the relative potency of your compound, allowing you to rank and prioritise lead compounds in the native physiological environment.
- CETSA® can accelerate your drug discovery pipeline by evaluating your compound’s target engagement in relevant tissues – before risks and costs escalate.