Is your compound actually therapeutic?

CETSA® easily transfers from cell line to animal tissue and human primary cells. Conventional affinity assays measuring a functional outcome or downstream pharmacodynamic effect are not reliable for a large number of potential drug targets, due to poor sensitivity, specificity or artefacts. By measuring a shift in the target’s melting temperature induced by binding of the ligand within the cell, CETSA® quantifies the potency of target engagement across a plethora of sample types and species, indicating whether or not your drug candidate will have a therapeutic effect in patients.

Key Learnings

  • CETSA® offers an artefact free measurement of target engagement to help you make informed decisions about your compound faster, with an assay that can be easily translated into relevant tissue and human samples.

Is your compound actually therapeutic? Download our CETSA® Translational Studies application note.


  1. Taylor-Stocke et al. Breast 2019
  2. Ishii et al. Nature Scientific Reports 2017

Speak to our experts

Learn how CETSA® can enable your project by talking to one of our Drug Discovery experts.