Is your compound actually therapeutic?

CETSA^® easily transfers from cell line to animal tissue and human primary cells. Conventional affinity assays measuring a functional outcome or downstream pharmacodynamic effect are not reliable for a large number of potential drug targets, due to poor sensitivity, specificity or artefacts. By measuring a shift in the target’s melting temperature induced by binding of the ligand within the cell, CETSA^® quantifies the potency of target engagement across a plethora of sample types and species, indicating whether or not your drug candidate will have a therapeutic effect in patients.