The need to discover new medicines
Why CETSA is the best way to measure target engagement
How CETSA overcomes challenges in early drug discovery
How CETSA HT enables more effective lead generation
How CETSA Classics enables more effective lead generation
Driving drug discovery forward.
Sneak peek at Chapter 1
One of society’s most pressing challenges today is to find new drugs that treat life-threatening and incurable diseases. However, despite increasing investment in research and development, the majority of candidates still fail in clinical trials. It’s thought that over half of these failures are due to a lack of efficacy in proof-of-concept trials – a subject of much debate in the industry.
These efficacy failures come at a considerablely high cost. Not only are substantial investments made for no gain, but a significant amount of lost time may also mean that pursuing that target is no longer a practical proposition. This is particularly detrimental for smaller companies that have invested all their resources in only one asset, and may mean they have to close down as a result. Another possible impact is on pharmaceutical companies that need to release new drugs to maintain their existing market share. In such situations, the company must either buy in a late-stage candidate drug (CD) from elsewhere, at great cost, or give up on a market in which they may have spent years developing.