Pelago webinar

March 22, 12:00 EST / 17:00 CET

Our Speaker:

Renato Alves

Project Advisor, Pelago Bioscience

Renato Alves obtained his doctorate in biochemistry from the University of Aveiro, Portugal. In 2016, he joined a newly appointed research group, at Karolinska Institutet in Stockholm, as a postdoctoral scientist. Since 2019, he has been working for Pelago Bioscience. Initially, as a Senior Scientist, he worked closely with several drug discovery companies, planning, executing, and leading CETSA projects in various formats adapted to the client’s needs. In 2022, he integrated the Commercial Operations team at Pelago Bioscience as a Project Advisor, where he acts as a scientific liaison for several key accounts and provides support in developing customized projects for our clients.

Register for free.

About the webinar

Targeted protein degradation using PROTACs® has become an important therapeutic strategy that has led to significant investments in the pharmaceutical industry. The modality holds considerable promise and a growing appreciation of the utility of PROTACs® as chemical probes for target identification and validation. As with other modalities, assuring efficacy from the early stages of drug discovery is essential to prevent failure at later stages of clinical development.


Pelago Bioscience can provide an integrated solution for your protein degrader program from hit identification to the mode of action confirmation. Leveraging on our patented Cellular Thermal Shift Assay (CETSA®), Pelago Bioscience can support the early stages of hit identification and validation in a high throughput manner with CETSA® Navigate HT. Applying the same AlphaLISA® immunoassay used in CETSA® Navigate HT, we can also effectively monitor protein degradation in the function of time and/or concentration of the PROTAC®, validating its activity. Finally, for a full characterization of your molecules, CETSA® Explore provides a proteome-wide analysis of the effects of the PROTAC® to assess its selectivity and with the potential to elucidate the MoA.