CETSA® Navigate (formerly known as Classics) is a targeted method applied to single selected proteins. Detection is based on Western Blot and is suitable for studies examining 1-10 compounds at a time.
This format is well-suited for early feasibility studies, hit confirmation, lead optimization, and translational work to progress your project to the next phase.
As a cellular target engagement assay that determines the level of interaction between a ligand and a target protein of interest in a physiologically relevant setting, CETSA® is perfectly suited for hit confirmation.
The aim at this stage of the drug discovery and development process is to optimize the compound properties to ensure the development of safe and effective candidate drugs (CDs) that can be dosed in healthy volunteers.
CETSA® can assess target engagement across a multitude of sample types. Established assays can easily be transferred from cell line to animal tissue, human primary cells, or patient-derived material, and thereby be used for translation all the way from lab bench to patient.
At Pelago, such projects are carried out routinely allowing rapid execution, from project start to final report the expected timeline is 8-10 weeks.
Check out our library to learn more about CETSA® Navigate. If you have any questions or want to see how CETSA® Navigate can be applied to your specific project, please contact us using the form below. We will get back to you as soon as we can.
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