Pelago Bioscience is a Drug Discovery Research Partner supporting preclinical and clinical drug discovery and development. The core of our service is the patented Cellular Thermal Shift Assay (CETSA®) and complementary functional and proteomics assays.
CETSA®, unlike other solutions on the market today, allows the assessment and quantification of target engagement under physiological conditions – without the need to modify the compound or protein.
Webinar Series
We share the latest CETSA® technology updates as well as the project updates from our clients by organizing webinars frequently. Our webinars are hosted by both Pelago and industry experts who have years of experience in their respective fields.
We hope you find our webinar recordings listed below helpful and informative. If you have any questions or feedback, please feel free to reach out to us.
Label-free validation of protein degraders using CETSA®
In this webinar, you will learn how Pelago Bioscience can support the early stages of hit identification and validation in a high throughput manner with CETSA® Navigate HT and how CETSA® Explore provides a proteome-wide analysis of the effects of the PROTACs® to assess their selectivity and with potential to elucidate the MoA.
CETSA® Explore – a mass spectrometry approach for target ID and compound profiling.
CETSA® Explore – an unbiased proteome-wide technology for target ID and compound profiling. Our speakers will present different applications of CETSA® Explore and highlight how this assay can help at various stages of drug discovery.
High Throughput CETSA® in Lead Generation
CETSA® is a powerful technology measuring target engagement in live cells, and can be applied to quantify binding to endogenously expressed proteins within disease-relevant cell backgrounds.
Biomarker Discovery with CETSA® Explore – Focus on protein status
Here we present some of the latest results and learnings from the CETSA® MS based Target Engagement Atlas (TEA). In this initiative we have used compressed CETSA® MS to map cellular responses to hundreds of well-known drugs and probes. The TEA allows us to identify hallmarks of cellular responses to several types of drugs and assign biomarkers beyond specific target engagement.
You can watch more video content and learn more how we can help you accelerate your drug discovery journey on our YouTube channel.