In this webinar, you will find a presentation by Dr. Joseph Shaw, Associate Principal Scientist, Discovery Sciences, R&D, AstraZeneca. To deliver the next generation of medicines, drug discovery must modulate increasingly novel and challenging targets. Identification of chemical…
In this webinar, you will find a presentation of various applications of CETSA® Explore, highlighting how this assay can assist at different stages of drug discovery. Date: 14 December 2022 Moderator: Jakub Lewicki, Operational Manager – Sales & Marketing, Pelago…
Here we present some of the latest results and learnings from the CETSA® Explore Target Engagement Atlas (TEA). In this initiative we have used compressed CETSA® Explore (PISA) to map cellular responses to hundreds of well-known drugs and probes. Date…
In this webinar, you will learn how Pelago Bioscience can support the early stages of hit identification and validation in a high throughput manner with CETSA® Navigate HT and how CETSA® Explore provides a proteome-wide analysis of the effects of the PROTACs® to…
In this webinar, you will find the details of the project where CETSA® Explore was leveraged to study the biological mechanism of the fungal polyketide lactone Brefeldin A (BFA) in human THP-1 cells. Fungal genomes encode a vast collection of chemical…
The Cellular Thermal Shift Assay is a method that allows the quantification of a compound’s Target Engagement (TE) within living cells or in disrupted cells. The CETSA® assay principle is based on the change in thermal denaturation profile of the…
Explore our E-Books and learn more about CETSA® technology and how it can be applied to your…
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Chernobrovkin at al., SLAS Discovery 2021, DOI: 10.1177/2472555220984372 Speak to our experts Learn how CETSA® can…
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Chernobrovkin at al., SLAS Discovery 2021, DOI: 10.1177/2472555220984372 Speak to our experts Learn how CETSA® can…