Search
Search results (15)
Ebooks
Explore your Chemistry and Navigate the Biology to Enhance your Drug Discovery Project
Why adopting CETSA® earlier is better? Download e-book and learn more...
Ebooks
Right tools, right time
How can I choose the most efficient and reliable target identification method...
Application Notes
Is your compound actually therapeutic?
Taylor-Stocke et al. Breast 2019 Ishii et al. Nature Scientific Reports 2017 Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery...
Application Notes
Is your target difficult to drug?
Martinez Molina et al. Science 2013 Soucek et al. Nat Rev Cancer 2017 Sexl et al. Int J Cancer 2020 Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery...
Application Notes
How does cellular target engagement relate to efficacy?
Martinez Molina et al. Science 2013 Jafari et al.Nature Protocols 2014 Ishii et al. Nature Scientific Reports 2017 Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery...
Application Notes
Is your target a hit?
Savitski et al. Science 2014 Hendricks et al. ACS Chem Bio Speak to our experts Learn how CETSA® can enable your project by talking to one of our Drug Discovery...
Posters
CETSA® Navigate HT: A New Paradigm For High-Throughput Screening
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Chernobrovkin at al., SLAS Discovery 2021, DOI: 10.1177/2472555220984372 Speak to our experts Learn how CETSA® can...
Posters
CETSA® For Navigating the Chemistry and Exploring the Biology of Protein Degraders
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Chernobrovkin at al., SLAS Discovery 2021, DOI: 10.1177/2472555220984372 Speak to our experts Learn how CETSA® can...
Posters
Measuring Protein Thermal Stability and Phosphorylation Changes to Capture Early Cellular Responses to Small Molecule Drugs
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Savitski M. M., Reinhard F. B. M., Franken H., Werner T., Savitski M. F., Eberhard D....
Posters
The Target Engagement Atlas - Mapping Cell Biology Through Small Molecule Perturbations
INTRODUCTION With the Cellular Thermal Shift Assay (CETSA®) celebrating its first decade since the PoC publication, the method has gained much interest in the basic science field as well as become an industry standard in applied drug discovery setting...
Posters
Multiplexed Mass Spectrometry Based Cellular Thermal Shift Assay: CETSA® Explore - As A Tool For Lead Optimization
Martinez Molina, D. et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science 341, 84-87 (2013) Savitski M. M., Reinhard F. B. M., Franken H., Werner T., Savitski M. F., Eberhard D....
Application Notes
Is your hit on target?
How can I confirm if my hit is on target? Download our CETSA® Navigate HT application note...
Application Notes
Is your protein degrader effectively driving the biology you desire?
Chernobrovkin, Alexey L. et al. SLAS discovery : advancing life sciences R & D vol. 26,4 (2021): 534-546. doi:10.1177/2472555220984372 Morgan, Paul et al. Drug discovery today vol. 17,9-10 (2012): 419-24. doi:10.1016/j. drudis.2011.12.020 Bunnage, Mark E et al. Nature chemical...
Application Notes
Discover the proteome with CETSA® Explore
CETSA® Explore for hit evaluation and target deconvolution Recent years have seen a resurgence in phenotypic drug discovery owing to its potential for delivering first-in-class treatments for diseases with unmet clinical needs1. However, one of the major challenges to...
Scientific publication
Mechanism of Action for Degraders
Targeted protein degradation is a novel modality with the potential to tackle therapeutically interesting proteins beyond the limitations of current existing approaches. In this area, CETSA® is a powerful technology which can be applied for investigating the degradation target...